受到影响的SARS-CoV-2特异性胎盘抗体转移
Caroline Atyeo1, Krista M Pullen2, Evan A Bordt3
1Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; PhD Program in Virology, Division of Medical Sciences, Harvard University, Boston, MA 02115, USA.
Cell
|January 21, 2021
概括
孕妇感染SARS-CoV-2,特别是在孕期的第三个月,会减少对婴儿的抗体转移. 这项研究揭示了抗体糖化和补偿机制的改变,为孕产妇的疫苗开发提供了洞察力.
科学领域:
- 免疫学
- 孕产妇和胎儿的医学
- 病毒学
背景情况:
- 孕妇患有更严重的SARS-CoV-2疾病.
- 母亲感染SARS-CoV-2对婴儿免疫转移的影响尚不清楚.
- 孕产妇感染可能会影响胎盘抗体转移,但机制尚不清楚.
研究的目的:
- 通过胎盘调查SARS-CoV-2特异性抗体的传输.
- 描述转移的抗体的Fc概况.
- 了解影响怀孕期间抗体转移的机制.
主要方法:
- 系统血清学用于分析抗体概况.
- 研究了针对流感,百日咳和SARS-CoV-2的特定抗体.
- 评估了胎盘转移和抗体的功能活性.
主要成果:
- 流感和百日咳特异性抗体的有效转移.
- 特别是在第三个月的感染中,SARS-CoV-2 特定抗体的转移显著减少.
- 减少的转移与抗体糖化变化有关,并通过增加的IgG和胎盘FCGR3A表达部分补偿.
结论:
- 母亲的SARS-CoV-2感染会影响新生儿的抗体转移.
- 改变的抗体糖化和胎盘因素影响了转移效率.
- 这些发现表明有补偿机制,并为孕产妇的疫苗策略提供信息.
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