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Updated: Nov 20, 2025

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在HGPS中抑制法尼西转移酶

Tom Misteli1

  • 1National Cancer Institute, NIH, Bethesda, MD, USA.

Cell
|January 22, 2021
PubMed
概括

哈森-吉尔福德孕病综合征 (HGPS) 是一种罕见的衰老疾病,由LMNA基因突变引起. 在HGPS患者中,Zokinvy治疗可以防止蛋白质化,减少血管硬,延长存活时间.

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Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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