心肌的氧气消耗,氧气供需异质性,以及区域性麻醉心肌中的微血管通透性
L D Stahl1, H R Weiss, L C Becker
1Department of Medicine, Johns Hopkins University School of Medicine, Balitmore, MD 21205.
Circulation
|April 1, 1988
概括
麻木的心肌消耗更多的氧气,尽管功能减少,表明能源效率低下或增加非收缩活动. 这表明震惊心肌中的焦点损伤.
科学领域:
- 心血管生理学心血管生理学
- 心肌的新陈代谢.
- 心脏麻醉的病理生理学
背景情况:
- 心脏正常的氧气消耗与机械工作相关.
- 麻醉的心肌可能表现出正常或高的氧气消耗,尽管功能受损.
研究的目的:
- 为了研究在麻醉心肌中氧气消耗和提取.
- 为了比较正常心脏区域与麻醉心脏区域的微血管功能.
主要方法:
- 微观光谱测量用于测量小冠状动脉和静脉中的氧和度.
- 放射性微球用于区域性心肌动脉血流评估.
- 微血管注射研究 (Microfil/ink) 用于评估血管通透性.
主要成果:
- 麻醉的心肌表现出较低的静脉氧和度,表明氧气提取和消耗增加.
- 尽管功能减弱,心肌血流和动脉氧和度在麻木和正常区域是相似的.
- 在麻醉区域观察到静脉氧和度的异质性增加,这表明伤害不均.
结论:
- 麻木的心肌表现出低效的能量转移或增加了对非收缩过程的能量使用.
- 麻醉心肌的损伤似乎是焦点的,分布不规则.
- 这些发现突出了心肌震荡中的代谢变化和异质性.
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