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Vasileios-Arsenios Lioutas^1,2, Cristina S Ivan³, Jayandra J Himali^2,4,5,6,7

¹Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

|January 26, 2021

概括

过渡性缺血性攻击 (TIA) 显著增加了中风的风险,风险增加了4. 37倍. 然而,TIA后90天的中风风险随着时间的推移而下降,近年来出现了显著的改善.

科学领域:

神经学
流行病学
公共卫生

背景情况:

对于有效的预防策略来说,精确估计中风风险是非常重要的.
了解TIA中风风险的时间趋势可以为公共卫生干预和资源分配提供信息.

研究的目的:

为了确定基于人口的TIA发病率.
分析TIA中风风险的时间和长期趋势.
将TIA患者的中风风险与对照组进行比较.

主要方法:

使用前性收集的Framingham心脏研究 (1948-2017) 数据进行的回顾性队列研究.
包括14059名没有TIA或中风病史的参与者,与没有TIA的对照组匹配TIA病例 (5:1比率).
对TIA发病率,短期和长期中风比例以及90天中风风险的时间趋势进行分析.

主要成果:

转移性心脏病发病率是每1000人/年中的1. 19.
与对照组相比,TIA患者的10年中风风险显著高 (0. 46),风险比为4. 37.
经过TIA的90天中风风险从1948年至1985年的16. 7%显著下降到2000年至2017年的5. 9%.

结论:

这种TIA与随后中风的风险大大增加有关.
近几十年来,TIA导致的中风风险呈显著下降趋势.
这些发现突显了随着时间的推移,TIA管理和中风预防的改善.

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