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Updated: Nov 19, 2025

Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes
11:33

Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes

Published on: March 12, 2013

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对1型长QT综合征进行抑制替代基因治疗

Steven M Dotzler1, C S John Kim1, William A C Gendron2

  • 1Department of Molecular Pharmacology & Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (S.M.D., C.S.J.K., W.Z., D.Y., J.M.B., D.J.T., M.J.A.), Mayo Clinic, Rochester, MN.

Circulation
|January 28, 2021
PubMed
概括

这项研究提出了一种针对长QT综合征 (LQT1) 的新型基因疗法,该疗法可以抑制和替代有缺陷的KCNQ1基因. 这种方法成功地纠正了患者衍生的细胞中的心脏再极化,为LQT1提供了潜在的分子治疗方法.

关键词:
人类的KCNQ1蛋白基因治疗诱导多能干细胞长时间QT综合征

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