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Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag
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一个由生长因子激活的溶酶体K道调节了帕金森病理

Jinhong Wie1, Zhenjiang Liu1, Haikun Song2

  • 1Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.

Nature
|January 28, 2021
PubMed
概括

一个新发现的溶酶体K+通道,lysoKGF,通过TMEM175变体将生长因子与帕金森病风险联系起来. 它的功能障碍会损害神经元,加速α-synuclein的积累.

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