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Updated: Nov 18, 2025

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates
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通过SCF-RBR E3-E3超级组件对F盒蛋白的结合

Daniel Horn-Ghetko1, David T Krist1,2, J Rajan Prabu1

  • 1Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany.

Nature
|February 4, 2021
PubMed
概括

由库林-RING (CRL) 和RBR型链酶形成的E3链酶超组件使各种基质的无处不在成为可能. 这种机制利用ARIH1和SCF连接酶来无处不在的基质与传统的E3连接酶系统不兼容.

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