细菌活性物质的时空顺序的粘性弹性控制
Song Liu1, Suraj Shankar2,3,4, M Cristina Marchetti5
1Department of Physics and Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, P. R. China.
Nature
|February 4, 2021
概括
研究人员通过改变液体粘弹性来控制细菌活性物质的自我组织. 这创造了可调节的振荡, 提供了指导活体物质流和开发软机器人的新方法.
科学领域:
- 活动物质物理学
- 软机器人
- 微生物学
背景情况:
- 活性物质系统,包括细菌,表现出复杂的自我组织,通常显示空间秩序或时间同步.
- 在活性物质中同时控制空间和时间组织通常需要复杂的相互作用或工程系统.
- 对于从生物系统到软机器人的应用来说, 了解和控制活性物质的动态是至关重要的.
研究的目的:
- 开发一种简单的技术,同时控制细菌活性物质的空间和时间自我组织.
- 研究液体粘性对细菌悬浮物的集体行为的影响.
- 展示一种利用气态特性指导活性物质流动的新方法.
主要方法:
- 封闭的密集悬浮的大肠杆菌 (一种细菌).
- 通过添加纯化的基因组DNA来操纵液体粘性.
- 结合实验观测与活性物质模型来分析行为.
主要成果:
- 实现了同时的空间和时间自我组织, 呈现为毫米尺度旋转.
- 观察到可调节频率的全球性周期性振荡,类似于扭矩摆.
- 通过积极强迫和粘弹性应力放松的相互作用来解释动力学.
结论:
- 证明一个单一的宏观参数 (流体粘性) 可以控制复杂的活性物质的自我组织.
- 这些发现为复杂液体中的细菌行为提供了潜在的健康和生态相关性.
- 可调节,自振动的细菌可以被视为软机器人和微流体设备的"时钟发生器".
相关概念视频
Actin Polymerization and Cell Motility
6.1K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
6.1K
Flagella and Motility in Bacteria
1.4K
Flagella are specialized, thread-like structures that extend from a bacteria's cell envelope. They play a crucial role in motility and chemotaxis. Their structural organization and functioning exemplify sophisticated biological engineering, enabling bacterial survival and adaptability in diverse environments.Structure of the FlagellumA bacterial flagellum consists of three key components: the filament, the hook, and basal body. The filament, a long, helical structure composed of repeating...
1.4K
Actin Treadmilling
9.0K
Actin filaments undergo polymerization and depolymerization from either end. The polymerization and depolymerization rates depend on the cytosolic concentration of free G-actins. The polymerization rate is generally higher at the plus or barbed end, while the depolymerization rate is higher at the minus or pointed end. At a steady state, critical concentration describes the concentration of free G-actin monomers at which the polymerization rate at the plus end is equal to that of the...
9.0K
Methods for Controlling Microbial Growth
1.2K
Microbial growth control refers to various methods employed to inhibit, reduce, or eliminate microorganisms to ensure safety and hygiene across different settings. These methods are categorized based on the target environment and the level of microbial control required.Biocides are versatile agents designed to control microorganisms by either inhibiting their growth or outright killing them. These agents work through various physical, chemical, mechanical, or biological mechanisms. The...
1.2K
Physical Methods for Controlling Microbial Growth: Temperature
726
Heat is a widely used method to control microbial growth by targeting and denaturing cellular proteins, thereby killing or inactivating microbes. This method's effectiveness is quantified using parameters such as the thermal death point (TDP), thermal death time (TDT), and decimal reduction time (D value). TDP represents the lowest temperature at which all microorganisms in a liquid suspension are eliminated within 10 minutes, whereas TDT is the time necessary to achieve sterilization at a...
726
Cell Motility through Blebbing
2.2K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
Blebbing Through the Matrix
In multicellular...
2.2K


