概括
在RECOVERY试验中,阿齐思罗米辛没有改善住院COVID-19患者的存活率. 它的使用应仅限于具有明确的抗菌指示的病例,而不是用于COVID-19治疗.
科学领域:
- 临床医学
- 传染性疾病
- 药理学
背景情况:
- 具有免疫调节性质的抗生素阿齐思罗米被研究用于COVID-19治疗.
- 这项研究评估了阿齐思罗米在住院的COVID-19患者的安全性和有效性.
研究的目的:
- 评估阿齐思罗米在住院COVID-19患者的临床结果的有效性.
- 确定阿兹罗米辛是否能降低该患者群体的28天死亡率.
主要方法:
- 一个随机的,受控的,开放的,适应性平台试验 (RECOVERY),涉及7,763名住院COVID-19患者.
- 患者接受了常规治疗加上阿齐思罗米辛 (每天500毫克) 或仅接受常规治疗.
- 主要结局是28天的全因死亡率.
主要成果:
- 阿兹罗米辛的使用没有显著改变28天全因死亡率 (22%在两组;率比为0. 97,95%CI为0. 87-1. 07).
- 在住院时间或28天生存率方面没有发现显著差异.
- 机械通风或死亡的综合终点也没有显著的差异.
结论:
- 阿齐思罗米辛在改善住院COVID-19患者的生存或其他临床结果方面无效.
- 在住院的COVID-19患者中使用阿兹罗米辛应保留在确诊的细菌感染的情况下.
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