慢性感染治疗期间SARS-CoV-2的演变
Steven A Kemp1, Dami A Collier1,2,3, Rawlings P Datir2,3
1Division of Infection and Immunity, University College London, London, UK.
Nature
|February 5, 2021
概括
在免疫抑制患者中,慢性SARS-CoV-2感染导致病毒进化和抗体抵抗. 康复期的血治疗选择了具有降低中和灵敏度的尖端蛋白变体.
科学领域:
- 病毒学
- 免疫学
- 基因组学
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 尖端蛋白通过ACE2受体促进病毒的进入,是中和抗体的关键目标.
- 了解慢性感染和治疗干预期间的病毒演变对于管理疾病进展至关重要.
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