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基于化学合成的同质葡萄糖形式,探测人体中N-葡萄糖的功能

Hongxing Li1, Jun Zhang1, Chuanjing An1

  • 1State Key Laboratory of Natural and Biomimetic Drugs, and Department of Chemical Biology at School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.

Journal of the American Chemical Society
|February 12, 2021
PubMed
概括

合成同质糖蛋白,如17A (IL-17A) 能够研究N-糖化功能. 复杂的N-glycans可以阻碍IL-17A受体的结合,影响其活性.

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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