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鼻内融合抑制性脂可以防止子的SARS-CoV-2直接接触传播

Rory D de Vries ¹, Katharina S Schmitz ¹, Francesca T Bovier ^2,3,4

¹Department of Viroscience, Erasmus MC, Rotterdam, Netherlands.
²Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
³Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
⁴Department of Experimental Medicine, University of Campania "Luigi Vanvitelli," Caserta, Italy.
⁵Department of Biomedical Engineering, Politecnico di Milano, Milan, Italy.
⁶Digizyme Inc., Brookline, MA, USA.
⁷Department of Physiology and Cellular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
⁸Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA.
⁹Center for Molecular and Cellular Dynamics, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
¹⁰Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
¹¹Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA. caa238@cornell.edu r.deswart@erasmusmc.nl am939@cumc.columbia.edu mp3509@cumc.columbia.edu.
¹²Department of Viroscience, Erasmus MC, Rotterdam, Netherlands. caa238@cornell.edu r.deswart@erasmusmc.nl am939@cumc.columbia.edu mp3509@cumc.columbia.edu.
¹³Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. caa238@cornell.edu r.deswart@erasmusmc.nl am939@cumc.columbia.edu mp3509@cumc.columbia.edu.
¹⁴Department of Microbiology and Immunology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.

⁰Department of Viroscience, Erasmus MC, Rotterdam, Netherlands.

Science (New York, N.Y.) +

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2021年二月18日

在PubMed上查看摘要

概括

新的脂融合抑制剂有效阻止了SARS-CoV-2感染. 每日鼻腔治疗完全防止了传染,为抗击COVID-19提供了潜在的预防策略.

科学领域

病毒学
药物发现
传染性疾病

背景情况

控制COVID-19大流行需要减少SARS-CoV-2的传播.
病毒进入宿主细胞是通过促进膜融合的尖端蛋白进行的.

研究的目的

设计和评估新的脂融合抑制剂.
在动物模型中评估这些抑制剂对SARS-CoV-2传播的预防效果.

主要方法

脂融合抑制剂旨在阻止尖端蛋白介导的膜融合.
进行了体外疗效和体内生物分布研究.
在SARS-CoV-2传播的模型中评估了一种二次性脂.

主要成果

脂抑制剂在阻止病毒进入方面表现出有效性.
每天鼻入服用二次性脂完全防止了中SARS-CoV-2的传播.
在严格的共同养模式中,未经治疗的对照动物都被感染了.

结论

脂融合抑制剂是预防SARS-CoV-2感染的有希望的策略.
鼻腔内脂可能提供一种稳定有效的预防措施来预防COVID-19的传播.
进一步的发展可能会导致易于翻译的鼻内预防.