短链脂肪酸在失败的心脏中超过氧化
Andrew N Carley1, Santosh K Maurya1, Matthew Fasano1
1Davis Heart and Lung Research Institute and Department of Internal Medicine, The Ohio State University College of Medicine, Columbus (A.N.C., S.K.M., M.F., Y.W., E.D.L.).
Circulation
|February 19, 2021
概括
短链脂肪酸 (SCFA) 在失败的心脏中比酸更容易氧化,提供新的能量来源. 这项研究探讨了SCFA作为能量缺乏的心脏的替代燃料.
科学领域:
- 心脏病学
- 生物化学
- 代谢研究
背景情况:
- 由于卡尼丁棕转移酶1 (CPT1) 的活性降低,心脏衰竭会导致长链脂肪酸 (LCFA) 氧化功能受损.
- 基氧化在失败的心脏中升高,作为产生ATP的替代碳来源.
- 短链脂肪酸 (SCFA) 也可以通过绕过CPT1来支持能量生产.
研究的目的:
- 研究SCFA作为心脏衰竭的替代能源的潜力.
- 为了比较SCFA和的氧化率在健康和缩的心脏.
- 检查与SCFA和代谢相关的酶表达的适应性变化.
主要方法:
- 通过横动脉收缩 (TAC) 在老鼠中诱导心脏缩和功能障碍.
- 与葡萄糖和棕酸盐 (LCFA) 一起注入13C标记的酸盐 (SCFA) 或D3酸盐 (酸盐).
- 使用13C核磁共振光谱测量了氧化率,并分析了酶表达.
主要成果:
- TAC诱导病理性缩,增加了对乙-CoA的贡献.
- 在失败的心脏中,酸盐 (SCFA) 氧化率比酸盐氧化率高15%,在假心脏中则高15%.
- 增加SCFA和氧化发生在LCFA氧化,减少LCFA对乙-CoA的贡献在SCFA perfused失败的心脏.
结论:
- 短链脂肪酸 (SCFA) 在失败的心脏中比酸更容易氧化.
- SCFA 是一个有前途的,但尚未被探索的替代碳来源,
- 心脏衰竭的代谢适应有利于绕过CPT1的基质的氧化,例如SCFA和.
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