血清阿尔多和血活动与非裔美国人的门诊血压的联系:杰克逊心脏研究
在PubMed上查看摘要
概括
此摘要是机器生成的。在非裔美国人中,较低的血蛋白活性 (PRA) 和较高的阿尔多水平与血压升高有关. 针对低蛋白活性可以改善该群体的高血压控制.
科学领域
- 心血管医学
- 内分泌学
- 高血压研究
背景情况
- 氨酸 - 氨酸 - 氨酸系统 (RAAS) 显著影响血压 (BP).
- 在非裔美国人中,RAAS组件与门诊血压 (ABP) 表型之间的关联仍未得到充分研究.
研究的目的
- 在非洲裔美国人中研究阿尔多斯特,血蛋白活性 (PRA) 和ABP监测表型之间的关系.
- 在这个人群中确定高血压管理的潜在治疗目标.
主要方法
- 使用了912名杰克逊心脏研究参与者的数据.
- 采用多变量回归分析来检查阿尔多,PRA和临床/健行血压之间的关联,包括高血压表型.
- 根据关键的混因素进行调整.
主要成果
- 在临床,清醒和睡眠期间,较低的PRA与较高的静脉和腹血压 (DBP) 相相关.
- 较高的阿尔多斯特水平与DBP的增加有关.
- 降低PRA与各种高血压类型的几率降低有关,包括掩盖和持续的高血压.
结论
- 非洲裔美国人的血压较高,因其抑制了蛋白活性和提高了氨酸水平.
- 较高的阿尔多水平与DBP的增加相关.
- 针对RAAS治疗的进一步研究对于改善非裔美国人的高血压控制至关重要.
相关概念视频
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...

