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Updated: Nov 16, 2025

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IL-12和IL-23受体共享的结构基础揭示了对T细胞与NK细胞形成作用的通道

Caleb R Glassman1, Yamuna Kalyani Mathiharan2, Kevin M Jude3

  • 1Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Cell
|February 19, 2021
PubMed
概括

研究人员设计了新的IL-12部分激动剂,可以选择性地激活CD8+T细胞,同时不影响NK细胞. 这些向性疗法显示出抗瘤免疫力有望降低毒性.

关键词:
一个IL-12一个IL-23免疫学受体生物学信号传输结构生物学

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