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在早产婴儿中的微生物群组的多王国生态驱动因素
Chitong Rao1, Katharine Z Coyte2,3, Wayne Bainter4
1Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Nature
|February 25, 2021
概括
微生物之间的相互作用, 不仅仅是环境或宿主, 驱动着早产婴儿的肠道微生物组组. 特定的相互作用,如克莱布西拉利用葡萄球菌, 塑造微生物群落对婴儿健康至关重要.
科学领域:
- 微生物组研究
- 婴儿健康
- 生态学
背景情况:
- 过早出生婴儿的肠道微生物群遵循可预测的组合模式.
- 这些动态的驱动因素在很大程度上是未知的.
- 了解这些力量对于早产儿的健康至关重要.
研究的目的:
- 确定早产婴儿肠道微生物组的关键驱动因素.
- 研究微生物相互作用对婴儿肠道生态系统的作用.
- 探索正在发展中的微生物群中的跨王国相互作用.
主要方法:
- 在178名早产儿的长度队列研究中.
- 多王国绝对丰度量化 (细菌,真菌,古生物).
- 生态建模和实验验证 (体外和体内).
主要成果:
- 观察到微生物的繁殖,灭绝,以及细菌和真菌负载之间的反向相关性.
- 证明特定的微生物相互作用,
- 鉴定出Candida albicans作为抑制主要肠道细菌的属性.
结论:
- 在早产婴儿中可预测的肠道微生物组是由指导的,取决于环境的微生物相互作用驱动的.
- 跨王国的相互作用显著影响了微生物群组.
- 微生物之间的相互作用是塑造宿主相关微生物群的核心,为目标干预提供了信息.
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