在营养限制期间,硫封存促进多细胞性
Beth Kelly1, Gustavo E Carrizo1, Joy Edwards-Hicks1
1Max Planck Institute for Immunobiology and Epigenetics, Freiburg, Germany.
Nature
|February 25, 2021
概括
在Dictyostelium discoideum中营养素的限制会触发反应性氧物种,将囊分离到谷氨中. 这种硫调节会阻止增殖,使多细胞发展,并突出氧和硫.
科学领域:
- 细胞生物学
- 生物化学
- 发育生物学
背景情况:
- 在饥饿时,Dictyostelium discoideum表现出依赖营养的行为变化,从单细胞转变为多细胞状态.
- 这种生物可以作为一种模型来理解新陈代谢如何影响细胞的分化和功能.
研究的目的:
- 研究反应性氧物种 (ROS) 在营养有限的Dictyostelium discoideum中的作用.
- 阐明硫代谢根据营养的可用性调节细胞命运和发育的机制.
主要方法:
- 在营养限制下对反应性氧物种的产生进行分析.
- 在谷氨中测量囊素的数量.
- 在蛋白质转化和铁硫酶活性中评估硫的利用.
主要成果:
- 营养物质的限制会诱导ROS,导致氨酸中囊的封存.
- 这种封存限制了线粒体代谢和细胞增殖的硫可用性.
- 通过ROS调节硫,保持非增殖状态,促进多细胞发育.
结论:
- 反应性氧物种作为信号分子,通过硫调节调解细胞命运决策.
- 在早期的真核生物中,氧和硫被认为是决定细胞命运的关键信号分子.
- 这些发现有助于理解多细胞生物对营养物质波动的细胞反应.
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