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一种基于器官的器官再利用方法来治疗短肠综合征
Shinya Sugimoto1,2, Eiji Kobayashi3, Masayuki Fujii1,4
1Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan.
Nature
|February 25, 2021
概括
研究人员使用大肠的器官制造了一种功能性的小肠. 这种再生方法通过恢复营养吸收和改善生存率,成功治疗大鼠短肠综合征 (SBS).
科学领域:
- 复原医学
- 胃肠病学
- 机器人技术
背景情况:
- 短肠综合征 (SBS) 是由于细肠切除而导致的,导致吸收不良.
- 目前的器官技术允许肠表皮在体外扩展,但难以重建复杂的淋巴血管系统.
- 在再生医学中重建完整的小肠仍然是一个重大挑战.
研究的目的:
- 开发一个功能小肠化结肠 (SIC) 使用骨衍生器官.
- 调查光流在形成中的作用.
- 在SBS的再生疗法中使用器官的原则证明.
主要方法:
- 将人类骨器官移植到小鼠结肠中,以评估区域特征和状组织的形成.
- 在体外培养有机单层,以研究光流对毛发育的影响.
- 通过将SIC重新定位在肠结处以暴露于肠汁,开发鼠标SIC模型.
主要成果:
- 人体皮质器官保持了区域特征,并在小鼠结肠中形成新生的皮质.
- 在实验室中发现光线流对形成至关重要.
- 鼠标SIC模型显示了小肠器官结构,包括血管,内膜,小和乳细胞.
- 在大鼠SBS模型中,SIC显示了吸收功能和改善了肠道衰竭.
- 在SBS模型中,结肠器官移植导致死亡.
结论:
- 功能性小肠结肠可以从骨衍生的器官生成.
- 在大鼠模型中,这种SIC策略有效地恢复了吸收功能并改善了SBS.
- 有机体技术为再生和SBS治疗提供了可行的和有前途的策略.
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