环境侮辱的标志
Annette Peters1, Tim S Nawrot2, Andrea A Baccarelli3
1Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany; Chair of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig-Maximilians-Universität München, 81377 Munich, Germany; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Cell
|March 3, 2021
概括
环境侮辱通过各种暴露危害全球健康. 这项研究确定了包括氧化应激和基因组改变在内的八个关键标志,
科学领域:
- 环境健康科学
- 毒理学
- 人类健康
背景情况:
- 全球人类健康受到空气,水,土壤和食物污染的严重影响.
- 接触各种化学物质和压力因素发生在职业,家庭和一般环境中.
- 了解环境暴露造成危害的机制对于公众健康至关重要.
研究的目的:
- 提出一个统一的框架来了解环境暴露对健康的不利影响.
- 识别和定义核心生物过程,或标志,环境侮辱的病原体.
- 解释复杂的环境混合物如何导致严重的健康后果.
主要方法:
- 基于现有科学文献的概念框架开发.
- 确定受环境压力因素影响的关键生物途径.
- 综合证据,将特定的环境暴露与健康结果联系起来.
主要成果:
- 八种环境侮辱的标志:氧化应激和炎症,基因组变化和突变,表观遗传变化,线粒体功能障碍,内分泌干扰,细胞间通信变化,微生物群落变化和神经系统功能障碍.
- 这些特征共同解释了人类一生中环境暴露的破坏性影响.
- 这一框架有助于阐明复杂环境混合物的微量度如何导致严重的健康影响.
结论:
- 这八个特征为了解环境引起疾病的生物学基础提供了一个全面的模型.
- 这一框架可以指导未来对环境暴露的具体机制和累积影响的研究.
- 认可这些特征对于制定有效的减轻环境健康风险的全球负担至关重要.
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