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在NMR,X射线晶体学和机器学习的指导下,概括Nrf2对KEAP1的结合 afinity

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    Journal of the American Chemical Society
    |March 8, 2021
    PubMed
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    宏环可以有效地向蛋白-蛋白相互作用 (PPI),如KEAP1-Nrf2相互作用. 优化循环形状,而不是残留物,显著增强了KEAP1的结合亲和力.

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