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Programmed Electrical Stimulation in Mice
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在人类心脏中广泛分布的心房起器综合体的演示
J P Boineau1, T E Canavan, R B Schuessler
1Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, MO 63110.
Circulation
|June 1, 1988
概括
这项研究表明,患有沃尔夫-帕金森-怀特综合征的患者有多个分布在心房的起器位点,而不仅仅是鼻节点. 这些节外部位在生理上起作用,这表明了控制心率的复杂系统.
科学领域:
- 电力生理学 电力生理学
- 心脏病学 心脏病学
- 心脏电生理学 心脏电生理学
背景情况:
- 沃尔夫 - 帕金森 - 怀特综合征的特征是辅助心房道.
- 动脉节律失常常常与这些辅助通路有关.
- 了解心房激活模式对于管理心律失常至关重要.
研究的目的:
- 在患有沃尔夫-帕金森-怀特综合征的患者中分析心房脱极化模式.
- 为了确定心房起器在各种节奏期间的起源和分布.
- 为了研究已识别的起器部位的功能行为.
主要方法:
- 在14名患者中记录了来自156个心房上心电极的双极电图.
- 在自发,鼻和过度节奏节奏节奏期间映射了心房激活.
- 使用鼻节恢复时间评估心脏起器功能.
主要成果:
- 识别了多个广泛分布的心房起器部位,超出了鼻节点,包括左心房部位.
- 观察到不同的脉冲启动模式 (单焦,外节,多中心).
- 发现控制和逃生节拍器都在生理上运行.
结论:
- 患有沃尔夫-帕金森-怀特综合征的患者表现出一个复杂的心房起器系统,分布在外节位.
- 这些发现支持了在人类中广泛分布的心房起器综合体的概念.
- 外节点在这个复杂的系统中,在节奏控制中起着生理作用.
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