生物启发的多样化方法 致力于液类类的总合成
Hannah M S Haley1, Stefan E Payer1, Sven M Papidocha1
1Department of Chemistry, University of California, Berkeley, California 94720, United States.
Journal of the American Chemical Society
|March 17, 2021
概括
研究人员使用创新的C-H功能化和C-C裂变策略实现了首次复杂的Lycopodium类化合物的总合成,包括casuarinine H和lycoplatyrines A/B. 这项工作扩展了异环合成化学方法.
科学领域:
- 有机化学
- 合成化学
- 自然产品合成
背景情况:
- 异环是制药和农业化学品中的关键支架.
- 需要先进的合成方法来选择性地功能化和修改这些结构.
研究的目的:
- 报告第一个特定的Lycopodium类化合物的总合成: casuarinine H, lycoplatyrine B, lycoplatyrine A 和 lycopladine F.
- 为了达到8,15-二珀A的总合成.
- 为了证明一种常见的前体的生物启发后期多样化.
主要方法:
- 使用了C-H功能化和C-C裂变方法.
- 使用氧化C-C键裂变的piperidine环.
- 进行了皮里丁核的选择性C-H玻里化,以进行交叉合.
主要成果:
- 已经成功合成了素H,素B,素A和素F.
- 完成了8,15-二素A的总合成.
- 为实现多样化,确定了一个常见的前体N-desmethyl-β-obscurine.
结论:
- 这项研究为复杂的Lycopodium化物提供了新的合成途径.
- 证明了晚期多元化策略的有用性.
- 构建异环的先进方法.
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