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Updated: Nov 12, 2025

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
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DPP9封存NLRP1的C端以抑制炎症酶激活

L Robert Hollingsworth1,2,3, Humayun Sharif1,2, Andrew R Griswold4,5

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

Nature
|March 18, 2021
PubMed
概括

双基酶8和9 (DPP8/DPP9) 通过与其C端片段相互作用来调节NLRP1炎症酶的激活. 像Val-boroPro这样的抑制剂会破坏这种相互作用,导致NLRP1的激活和炎症反应.

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