COVID-19 和人类天生的免疫系统
Joachim L Schultze1, Anna C Aschenbrenner2
1Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; PRECISE Platform for Single Cell Genomics and Epigenomics at the DZNE and the University of Bonn, Bonn, Germany; Genomics and Immunoregulation, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Cell
|March 20, 2021
概括
天生的免疫系统的变化影响严重急性呼吸系统冠状病毒2 (SARS-CoV-2) 疾病的严重程度. 了解这些免疫相互作用是开发COVID-19诊断和治疗方法的关键.
科学领域:
- 免疫学
- 病毒学
- 病理生理学
背景情况:
- 严重急性呼吸系统冠状病毒2 (SARS-CoV-2) 导致全球卫生危机.
- 天生的免疫力是对包括SARS-CoV-2在内的病毒感染的主要防御.
- 2019年冠状病毒疾病 (COVID-19) 的异质性疾病过程表明存在潜在的免疫系统变异.
研究的目的:
- 建立一种连接天生的免疫力和SARS-CoV-2感染的概念框架.
- 将临床观察与大流行第一年的实验发现联系起来.
- 探索先天性免疫变异如何对COVID-19疾病谱产生影响.
主要方法:
- 审查有关先天免疫和SARS-CoV-2的现有文献和实验结果.
- 人类天生的免疫系统与病毒之间的相互作用的概念合成.
- 对影响疾病结果的免疫成分变异性的证据分析.
主要成果:
- 天生的免疫组件的变异性对COVID-19疾病呈现的多样性起着显著的作用.
- 在SARS-CoV-2病理生理学中,特定的细胞和可溶性免疫媒介起着至关重要的作用.
- 天生的免疫和SARS-CoV-2之间的相互作用是复杂的和多因素的.
结论:
- 了解天生的免疫机制对于开发COVID-19诊断标志物至关重要.
- 针对天生的免疫力为COVID-19提供了潜在的治疗策略.
- 需要进一步的研究来确定因果关系并推进临床应用.
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