Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Central Dogma01:20

The Central Dogma

30.6K
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
30.6K
The Central Dogma01:25

The Central Dogma

134.3K
Overview
134.3K
What is Genetic Engineering?00:49

What is Genetic Engineering?

76.8K
Overview
76.8K
From DNA to Protein03:06

From DNA to Protein

20.8K
The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
20.8K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

8.6K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
8.6K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

2.9K
2.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Secondary analysis of influenza a virus-infected cells at single-cell resolution reveals host BANF1 response to individual and combinations of detected segments.

Virology journal·2026
Same author

Discovery, implications and initial use of semi-synthetic organisms with an expanded genetic alphabet/code.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2023
Same author

Transcriptional processing of an unnatural base pair by eukaryotic RNA polymerase II.

Nature chemical biology·2021
Same author

Efforts toward Further Integration of an Unnatural Base Pair into the Biology of a Semisynthetic Organism.

Journal of the American Chemical Society·2021
Same author

Protein expression and purification of G-protein coupled receptor kinase 6 (GRK6), toward structure-based drug design and discovery for multiple myeloma.

Protein expression and purification·2021
Same author

Evidence that specific interactions play a role in the cholesterol sensitivity of G protein-coupled receptors.

Biochimica et biophysica acta. Biomembranes·2021
Same journal

Linker Engineering toward NIR-II Metal-Organic Framework with Maximal Emission beyond 1000 nm for Inflammatory Bowel Disease Imaging.

Journal of the American Chemical Society·2026
Same journal

Observing Kinetic Selectivity in Anthracene Photodimerization through Selective Quenching by Excited States of Proximate Rare Earth Cations.

Journal of the American Chemical Society·2026
Same journal

Sequence-Dependent Folding of Recognition-Encoded Melamine Oligomers.

Journal of the American Chemical Society·2026
Same journal

Large Thermo- and Mechanosalient Actuation via Cooperative Twist Elasticity-Induced Packing Motif Conversion.

Journal of the American Chemical Society·2026
Same journal

Discovery and Biosynthesis of Lanthipeptides Featuring an Azepinoindole Scaffold by Radical <i>S</i>-Adenosylmethionine Enzyme-Catalyzed C-C Bond Formation.

Journal of the American Chemical Society·2026
Same journal

Enantiopurity-Controlled Magnetism in a Two-Dimensional Organic-Inorganic Material.

Journal of the American Chemical Society·2026
查看所有相关文章

相关实验视频

Updated: Nov 11, 2025

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells
14:02

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells

Published on: April 9, 2018

8.8K

基因编码扩展:发明,开发,商业化

Miglena Manandhar1, Eugene Chun1, Floyd E Romesberg1

  • 1Synthorx, a Sanofi Company, La Jolla, California 92037, United States.

Journal of the American Chemical Society
|March 23, 2021
PubMed
概括
此摘要是机器生成的。

基因编码扩展 (GCE) 能够产生具有增强疗效的新型蛋白质. 本综述侧重于大肠杆菌中的GCE,其商业化以及蛋白质治疗的未来潜力.

更多相关视频

Super-Resolution Imaging of Bacterial Secreted Proteins Using Genetic Code Expansion
13:11

Super-Resolution Imaging of Bacterial Secreted Proteins Using Genetic Code Expansion

Published on: February 10, 2023

1.7K
Residue-specific Incorporation of Noncanonical Amino Acids into Model Proteins Using an Escherichia coli Cell-free Transcription-translation System
11:47

Residue-specific Incorporation of Noncanonical Amino Acids into Model Proteins Using an Escherichia coli Cell-free Transcription-translation System

Published on: August 1, 2016

16.2K

相关实验视频

Last Updated: Nov 11, 2025

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells
14:02

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells

Published on: April 9, 2018

8.8K
Super-Resolution Imaging of Bacterial Secreted Proteins Using Genetic Code Expansion
13:11

Super-Resolution Imaging of Bacterial Secreted Proteins Using Genetic Code Expansion

Published on: February 10, 2023

1.7K
Residue-specific Incorporation of Noncanonical Amino Acids into Model Proteins Using an Escherichia coli Cell-free Transcription-translation System
11:47

Residue-specific Incorporation of Noncanonical Amino Acids into Model Proteins Using an Escherichia coli Cell-free Transcription-translation System

Published on: August 1, 2016

16.2K

科学领域:

  • 生物化学
  • 分子生物学
  • 生物技术

背景情况:

  • 蛋白质是由20种标准的氨基酸合成的.
  • 遗传密码扩展 (GCE) 允许结合非正规氨基酸 (ncAAs).
  • 这扩大了蛋白质的功能和治疗潜力.

研究的目的:

  • 审查GCE的历史和现状.
  • 分析GCE用于蛋白质治疗的商业化.
  • 讨论所学到的经验和未来的方向.

主要方法:

  • 专注于大肠杆菌中的GCE方法.
  • 对学术和早期商业化工作的审查.
  • 分析GCE实施中的挑战和成功.

主要成果:

  • GCE正在从学术研究转向商业应用.
  • 早期的商业化努力提供了宝贵的教训.
  • 大肠杆菌是GCE发展的关键宿主.

结论:

  • GCE的方法正在快速发展.
  • 蛋白质疗法的常规优化正在成为可能.
  • 这将带来革命性的治疗蛋白质开发.