基因编码扩展:发明,开发,商业化
Miglena Manandhar1, Eugene Chun1, Floyd E Romesberg1
1Synthorx, a Sanofi Company, La Jolla, California 92037, United States.
Journal of the American Chemical Society
|March 23, 2021
概括
基因编码扩展 (GCE) 能够产生具有增强疗效的新型蛋白质. 本综述侧重于大肠杆菌中的GCE,其商业化以及蛋白质治疗的未来潜力.
科学领域:
- 生物化学
- 分子生物学
- 生物技术
背景情况:
- 蛋白质是由20种标准的氨基酸合成的.
- 遗传密码扩展 (GCE) 允许结合非正规氨基酸 (ncAAs).
- 这扩大了蛋白质的功能和治疗潜力.
研究的目的:
- 审查GCE的历史和现状.
- 分析GCE用于蛋白质治疗的商业化.
- 讨论所学到的经验和未来的方向.
主要方法:
- 专注于大肠杆菌中的GCE方法.
- 对学术和早期商业化工作的审查.
- 分析GCE实施中的挑战和成功.
主要成果:
- GCE正在从学术研究转向商业应用.
- 早期的商业化努力提供了宝贵的教训.
- 大肠杆菌是GCE发展的关键宿主.
结论:
- GCE的方法正在快速发展.
- 蛋白质疗法的常规优化正在成为可能.
- 这将带来革命性的治疗蛋白质开发.
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