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通过两个人工分子机器并行操作进行序列选择性解合成

Javier Echavarren¹, Malcolm A Y Gall¹, Adrian Haertsch¹

¹Department of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, U.K.

Journal of the American Chemical Society

|March 25, 2021

概括

两台基于罗塔的分子机器通过并行操作合成了十. 这种先进的方法模仿了生物蛋白质的修饰,

科学领域:

超分子化学
合成化学
生物技术

背景情况:

分子机器可以精确控制化学合成.
复杂的合成仍然是传统方法的挑战.
模仿生物过程可以激发新型合成策略.

研究的目的:

通过两台平行基于罗塔的分子机器合成一个十.
展示一种复杂组合的新方法.
探索分子机器在模仿生物翻译后修改方面的潜力.

主要方法:

在一个容器中同时运行两个分子合成器.
选择性残留激活和中间体的定向结合.
使用氨酸转化为氨酸和宏环-氨酸结合.
使用Glu残留物释放产品和清除机器.

主要成果:

通过四个阶段的过程成功制备了十.
在六介质中证明了二烯的选择性转化为囊.
通过宏循环-液链接实现中间体的定向结合.
能够同时释放产品并使用Glu残留物去除组装机械.

结论:

基于罗塔的分子机器可以并行运行复杂的十合成.
开发的系统模仿了生物结合和翻译后的修饰.
这种方法扩大了分子机器合成具有挑战性的生物分子的能力.

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