在英格兰评估SARS-CoV-2系B.1.1.7的传染性
Erik Volz1, Swapnil Mishra2, Meera Chand3
1MRC Centre for Global Infectious Disease Analysis, Jameel Institute for Disease and Emergency Analytics, Imperial College London, London, UK. e.volz@imperial.ac.uk.
Nature
|March 26, 2021
概括
在英国发现的SARS-CoV-2 B.1.1.7变种具有显著的传播优势. 这种变种也被称为关注变种 (VOC) 202012/01,比其他变种更容易传播50-100%.
科学领域:
- 病毒学
- 流行病学
- 基因组学
背景情况:
- 2020年底在英国出现了SARS-CoV-2 B.1.1.7系 (VOC 202012/01).
- B.1.1.7的快速扩散表明有选择性的优势,需要对其传染性进行调查.
研究的目的:
- 评估SARS-CoV-2 B.1.1.7变种的传染性.
- 将B.1.1.7的传播动态与其他流传的SARS-CoV-2血统进行比较.
主要方法:
- 来自社区测试的全基因组SARS-CoV-2序列数据和S基因目标失败 (SGTF) 的分析.
- 用基因组和SGTF数据估计B.1.1.7和其他谱系的时间变化的繁殖数量.
主要成果:
- 与非VOC血统相比,VOC B.1.1.7具有显著更高的传播能力 (50-100%的繁殖数量).
- 在推断VOC频率时,SGTF数据密切跟踪基因组数据.
- 在20岁以下的个体中,B.1.1.7感染的病例短暂增加.
结论:
- SARS-CoV-2 B.1.1.7 变种具有相当大的传播优势.
- 尽管观察到病例人口结构的变化,但B.1.1.7的传染性在不同年龄组中似乎没有显著差异.
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