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SARS-CoV-2 501Y.V2 通过康复期血脱离中和

Sandile Cele^1,2, Inbal Gazy^2,3,4, Laurelle Jackson¹

¹Africa Health Research Institute, Durban, South Africa.

|March 29, 2021

概括

南非COVID-19患者的中和抗体对501Y.V2变种的有效性降低. 然而,基于令人担忧的变种的疫苗可能会对其他SARS-CoV-2血统保持活性.

科学领域:

病毒学
免疫学
流行病学

背景情况:

有关SARS-CoV-2的变种 (VOC) 可以独立出现,并可能降低疫苗的疗效.
在南非的第二波COVID-19感染期间出现了501Y.V2 (B.1.351) VOC.
了解变种中和对于疫苗开发和公共卫生战略至关重要.

研究的目的:

将非VOC的SARS-CoV-2变种与501Y.V2 VOC的中和进行比较.
评估南非不同波段感染的个体血对这些变体的疗效.
根据VOC序列提供疫苗潜在有效性的证据.

主要方法:

在南非两次感染浪潮期间,使用住院的COVID-19患者的血进行了活病毒中和测定.
病毒序列测定用于描述涉及第一波感染的SARS-CoV-2菌株.
通过对非VOC和501Y.V2变体进行抗体反应比较来衡量中和效果.

主要成果:

第二波的等离子有效地中和了501Y.V2变种.
第一个波的血对501Y.V2变体进行了很差的交叉中和 (15.1倍减少).
通过第二波血对第一波变异进行交叉中和更有效 (减少了2. 3倍).

结论:

这种501Y.V2变种表现出较早感染的血中和减少.
使用VOC序列设计的疫苗可能会对其他流通的SARS-CoV-2血统提供保护.
这表明针对变异性尖端糖蛋白的疫苗具有潜在的交叉保护能力.

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