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Updated: Nov 11, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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DCAF11 支持通过电友蛋白质溶解向化马的向蛋白质降解

Xiaoyu Zhang1, Lena M Luukkonen2, Christie L Eissler2

  • 1The Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92307, United States.

Journal of the American Chemical Society
|March 30, 2021
PubMed
概括

新的电友蛋白质分解向基因组 (PROTACs) 向DCAF11,这是一个以前未被描述的E3链酶. 这一发现扩大了针对人类细胞蛋白质降解的工具包, 包括癌症治疗.

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