社会语音沟通的灵活扩展和持续性
Jingyi Chen1,2, Jeffrey E Markowitz3, Varoth Lilascharoen4
1Department of Neuroscience, Scripps Research, La Jolla, CA, USA.
Nature
|April 1, 2021
概括
小鼠可以灵活地调整超声波发声 (USV) 以进行社交交流. 一个涉及横向前视区域 (LPOA) 神经元的新型电路消毒了周水管灰色 (PAG),控制了USV的强度和持续时间.
科学领域:
- 神经科学
- 动物的行为
- 进行沟通
背景情况:
- 声调对于跨物种的社会沟通至关重要.
- 在小鼠中,求爱超声波声 (USV) 是由雌性气味触发的.
- 灵活的发声扩展和神经控制的机制尚不清楚.
研究的目的:
- 研究小鼠灵活发声缩放的基础神经回路.
- 确定控制超声波发声幅度和持续时间的特定神经元和通路.
- 了解社会环境如何影响发音参数.
主要方法:
- 对表达雌激素受体1 (ESR1) 的侧向前视区域 (LPOA) 神经元的光遗传激活.
- 在小鼠大脑中进行神经追踪和功能记录.
- 在不同的刺激条件下分析超声波发声 (USV) 参数 (幅度,持续时间).
主要成果:
- 激活LPOAESR1神经元可以引起各种求爱的USV.
- 一个消毒电路动机:LPOA神经元抑制局部周水管灰色 (PAG) 内神经元,释放USV门神经元.
- 延迟抑制恢复延长了USV发作,证明了灵活的控制.
结论:
- 通过LPOA-PAG抑制途径,可以灵活控制USV的噪音和发作时间.
- 这种电路模式对于小鼠的适应性语音社交沟通至关重要.
- 研究结果提供了关于哺乳动物声音灵活性的神经基础的见解.
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