一个抑制社会参与的杏仁体电路
Jeong-Tae Kwon1,2, Changhyeon Ryu1,2, Hyeseung Lee1,2,3
1Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nature
|April 1, 2021
概括
研究人员在小鼠中发现一种神经通路, 这涉及后中皮层桃体 (COApm) 和释放甲状腺激素 (TRH),对于评估社会风险至关重要.
科学领域:
- 神经科学
- 行为生物学
- 动物的行为
背景情况:
- 像交配这样的天生的社会行为至关重要,
- 评估和抑制危险的社交交互的神经机制尚不清楚.
研究的目的:
- 确定控制与不健康雌性交配的神经回路.
- 阐明特定大脑区域和神经调节器在社会风险评估中的作用.
主要方法:
- 在小鼠身上进行解剖学追踪和功能成像.
- 循环层次的表皮分析.
- 操纵神经活动和受体功能.
主要成果:
- 皮质桃体的后中核 (COApm) 对于抑制与不健康的雌性交配至关重要.
- 通过甲状腺释放激素 (TRH) 的介导,COApm向中枢桃体 (MEA) 投射.
- 在MEA中,TRH信号调节基于雌性健康状况的交配行为.
结论:
- 一个涉及COApm,MEA和TRH的新的神经通路调节了基于健康状况的社会互动.
- 这种机制使个人能够平衡社会成本和收益,防止疾病传播.
- 选择伴侣的缺陷可能会对健康产生重大影响.
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