乳腺癌
Sibylle Loibl1, Philip Poortmans2, Monica Morrow3
1German Breast Group, Neu-Isenburg, Germany; Centre for Haematology and Oncology Bethanien, Frankfurt, Germany.
Lancet (London, England)
|April 4, 2021
概括
乳腺癌的治疗已经以分子和免疫标志物发展,使个性化新辅助疗法和缓解辐射疗法成为可能. 针对性药物和免疫疗法现在为转移性疾病提供了量身定制的选择.
科学领域:
- 癌症学
- 分子生物学
- 免疫学
背景情况:
- 乳腺癌仍然是全球领先的癌症,
- 关键标志物包括免疫组织化学 (ER,PR,HER2,Ki-67),基因组 (BRCA1/ 2,PIK3CA) 和免疫标志物 (TIL,PD- L1).
研究的目的:
- 突出乳腺癌诊断和治疗方面的进步.
- 为了强调基于分子分析的个性化医疗的转变.
主要方法:
- 对现有结合多种生物标志物的诊断算法的审查.
- 分析新辅助和转移性治疗策略,包括向药物和免疫治疗.
主要成果:
- 新辅助组合疗法 (HER2阳性,三阴性) 是标准的,指导手术缓解和治疗后的策略.
- 基于风险的内分泌治疗 (5-10年) 和化疗用于ER阳性瘤.
- 转移性治疗包括CDK4/ 6,PI3K,PARP抑制剂和针对瘤的抗PD- L1免疫疗法.
结论:
- 乳腺癌的治疗越来越复杂,
- 个性化治疗策略正在成为标准, 从新辅助护理到转移性疾病的管理.
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