消除高发病率地区的产后艾滋病毒传播:需要补充生物医学干预措施
Philippe Van de Perre1, Ameena Goga2, Nobubelo Ngandu3
1Pathogenesis and Control of Chronic and Emerging Infections, INSERM, University of Montpellier, Etablissement Français du Sang, Antilles University, CHU Montpellier, Montpellier, France.
Lancet (London, England)
|April 4, 2021
概括
通过母乳养感染艾滋病毒的情况正在上升. 迫切需要新的生物医学策略来消除这种传播途径,
科学领域:
- 传染性疾病
- 公共卫生
- 免疫学
背景情况:
- 艾滋病毒母婴传播 (MTCT) 仍然是一个重大的全球卫生挑战.
- 虽然由于抗逆转录病毒疗法 (ART) 导致子宫内和产后MTCT的发生率正在下降,但通过母乳养的MTCT却在比例上升.
- 低于最佳的ART坚持,未经治疗的母体艾滋病毒和产后艾滋病毒感染增加了产后MTCT的风险.
研究的目的:
- 通过母乳养与其他传播途径相比,艾滋病毒MTCT的增长率要突出.
- 强调目前消除与母乳养相关的MTCT的潜在不足.
- 倡导紧急评估和实施新的生物医学干预措施.
主要方法:
- 对艾滋病毒的MTCT当前趋势的回顾.
- 通过母乳养增加MTCT的因素分析.
- 确定潜在的新生物医学预防策略.
主要成果:
- 与其他传播途径相比,母乳养的MTCT感染率正在上升.
- 目前的策略,如果不普遍应用,可能无法通过母乳养消除MTCT.
- 在通过母乳养预防产后艾滋病毒传播方面存在差距.
结论:
- 从母乳养中消除MTCT需要紧急实施额外的生物医学策略.
- 预防策略包括风险母乳养妇女的暴露前预防,产后强化 (重新检测,护理,婴儿预防) 和免疫预防 (疫苗或抗体).
- 针对性干预在艾滋病毒流行和发病率高的环境中至关重要.
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