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在小肠中,CAR指导T细胞适应胆汁酸

Mei Lan Chen1,2, Xiangsheng Huang3, Hongtao Wang3

  • 1Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA.

Nature
|April 8, 2021
PubMed
概括

核受体CAR通过调节MDR1表达来保护小肠免疫细胞免受胆酸毒性. 这一发现为治疗克罗恩病和相关小肠炎症提供了新的策略.

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