人体肠道微生物组的长期遗传稳定性和个体特异性
Lianmin Chen1, Daoming Wang2, Sanzhima Garmaeva2
1Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713GZ, the Netherlands; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen 9713GZ, the Netherlands.
Cell
|April 10, 2021
概括
这项研究显示了4年来肠道微生物组的稳定性, 这些特征将肠道细菌及其代谢物与宿主心脏代谢健康联系起来.
科学领域:
- 微生物学
- 人类生理学
- 代谢学
背景情况:
- 肠道微生物组的长期稳定性及其与宿主生理学的关系尚未完全理解.
- 个体特异性的微生物概况可以提供对宿主健康的见解.
研究的目的:
- 在人体表型和血代谢物方面,对四年内肠道微生物的稳定性和变化进行表征.
- 开发一种微生物指纹方法来分类纵向的基因组样本.
- 确定肠道微生物组与宿主心脏代谢健康之间的关联.
主要方法:
- 在4年间对338名患者进行了纵向跟踪,追踪了肠道微生物组,51种人类表型和1,183种血代谢物.
- 使用细菌单核酸多态 (SNP) 和结构变异的微生物指纹方法的开发.
- 将指纹方法应用于独立的人类微生物组项目 (HMP) 队列.
主要成果:
- 在一个独立的队列中,微生物指纹采集方法在4年间隔的样本中达到高达85%的准确性,在1年间隔的样本中达到95%.
- 观察到细菌物种丰富度,代谢途径和菌株替代的时间变化.
- 鉴定了190个与宿主表型的纵向微生物关联,以及519个与血代谢物,这些代谢物富含心脏代谢特征,维生素B和尿素毒素.
结论:
- 个体肠道微生物组的概况是暂时稳定的,可以准确地捕获指纹.
- 肠道微生物组组成及其代谢物与宿主心脏代谢健康具有纵向关联.
- 肠道微生物代谢物可能会调解微生物群对心脏代谢健康的影响.
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