视觉皮层中的高精度编码
Carsen Stringer1, Michalis Michaelos1, Dmitri Tsyboulski1
1HHMI Janelia Research Campus, Ashburn, VA 20147, USA.
Cell
|April 15, 2021
概括
鼠标视觉皮层中的神经可变性不会限制感知. 而是下游的大脑区域动态地处理感官信息,
科学领域:
- 神经科学
- 计算神经科学
- 感官处理
背景情况:
- 视觉皮层中的单个神经元具有可变性,可能会限制刺激编码.
- 单个神经元在神经群体中的变异性及其对全球刺激编码的影响的相关性仍然不清楚.
研究的目的:
- 调查视觉皮层的神经变异性是否与大量人群相关.
- 确定感官区分任务中的限制来源.
主要方法:
- 在小鼠初级视觉皮层 (V1) 和高级视觉区域同时记录多达5万个神经元.
- 在方向解码任务中测量刺激歧视值.
- 分析神经变化及其与行为表现的关系.
主要成果:
- 神经区分门明显低于行为门 (几乎是100倍).
- 行为变异性无法通过V1的神经变异性来解释.
- 与行为相关的神经活动源于非感官大脑区域的动态网络.
结论:
- 在小鼠中,感知区分是下游解码器所限制的,而不是感官表现中的神经噪声.
- 视觉皮层中的感官表现非常精确.
- 非感官大脑网络在感官感知中起着至关重要的作用.
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