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Updated: Nov 9, 2025

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
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通过瘤转录组进行合成致死性介导的精确瘤学

Joo Sang Lee1, Nishanth Ulhas Nair2, Gal Dinstag3

  • 1Cancer Data Science Lab, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Next Generation Medicine Lab, Department of Artificial Intelligence & Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon 16419, Republic of Korea; Department of Digital Health & Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Samsung Medical Center, Sungkyunkwan University, Seoul 06351, Republic of Korea.

Cell
|April 15, 2021
PubMed
概括

一个新的精确瘤框架SELECT使用瘤转录组数据来预测癌症治疗反应. 这种方法在35个临床试验中显示出80%的准确性, 扩大了个性化癌症治疗选择.

关键词:
癌症免疫疗法患者分层精密瘤学合成杀伤性合成救援转录组学

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