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Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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Updated: Jun 13, 2026

Recording Large-scale Neuronal Ensembles with Silicon Probes in the Anesthetized Rat

Recording Large-scale Neuronal Ensembles with Silicon Probes in the Anesthetized Rat

Published on: October 19, 2011

神经像素2.0:微型高密度探测器,可稳定,长期记录大脑

Nicholas A Steinmetz^1,2, Cagatay Aydin³, Anna Lebedeva⁴

¹UCL Institute of Ophthalmology, University College London, London, UK. nick.steinmetz@gmail.com m.carandini@ucl.ac.uk harrist@janelia.hhmi.org.

Science (New York, N.Y.)

|April 16, 2021

概括

这项研究引入了Neuropixels 2.0探测器和用于长期神经记录的新算法. 这些工具可以稳定地跟踪数以千计的神经元,

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Hybrid Microdrive System with Recoverable Opto-Silicon Probe and Tetrode for Dual-Site High Density Recording in Freely Moving Mice

Hybrid Microdrive System with Recoverable Opto-Silicon Probe and Tetrode for Dual-Site High Density Recording in Freely Moving Mice

Published on: August 10, 2019

The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice

The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice

Published on: July 26, 2024

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Last Updated: Jun 13, 2026

Recording Large-scale Neuronal Ensembles with Silicon Probes in the Anesthetized Rat

Recording Large-scale Neuronal Ensembles with Silicon Probes in the Anesthetized Rat

Published on: October 19, 2011

Hybrid Microdrive System with Recoverable Opto-Silicon Probe and Tetrode for Dual-Site High Density Recording in Freely Moving Mice

Hybrid Microdrive System with Recoverable Opto-Silicon Probe and Tetrode for Dual-Site High Density Recording in Freely Moving Mice

Published on: August 10, 2019

The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice

The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice

Published on: July 26, 2024

科学领域:

神经科学
神经工程

背景情况:

了解神经处理动态需要长期监测神经活动.
现有技术在小型动物的可扩展性和慢性植入方面存在局限性.

研究的目的:

开发高级神经探测器和分析方法,用于高密度的长期记录.
在小型哺乳动物中进行长期植入和记录.

主要方法:

引入Neuropixels 2.0探测器,使用超过5000个记录点.
开发新的数据处理算法,用于对脑部运动进行后期纠正.
在多个实验室的老鼠和老鼠中长期植入.

主要成果:

长时间 (几个月) 的可靠高质量的神经记录.
从数千个神经元的稳定记录在不受约束的行为.
在小哺乳动物如老鼠和老鼠中成功应用.

结论:

神经像素2.0探测器和相关算法显著提升了长期神经记录的能力.
这些工具有助于研究自然行为的神经动力学.
在小型动物模型中实现稳定,大规模的神经记录.