呼吁采取新的全球方法解决心血管疾病的药物解决方案
Gemma A Figtree1, Keith Broadfoot2, Barbara Casadei3,4,5
1Kolling Institute, Royal North Shore Hospital, University of Sydney, Australia (G.A.F.).
Circulation
|April 20, 2021
概括
开发新的心血管疗法需要药物发现和患者分层的创新. 投资于先进的分子和成像技术可以加速针对心血管疾病的向治疗.
科学领域:
- 心血管医学
- 药物治疗
- 药物发现
背景情况:
- 对冠状动脉疾病,心力衰竭和高血压等主要心血管疾病的药物治疗存在重大差距.
- 目前的药物开发途径漫长,成本高昂,成功率低,尽管疾病负担很高,但制止了行业投资.
研究的目的:
- 强调对心血管疾病的新疗法进行持续投资的必要性.
- 探索改善药物发现,患者分层和临床转换的机会.
主要方法:
- 通过改进的成像和基于生物机制的分子标记来利用先进的患者表型.
- 使用无偏见的"omic"方法来发现新的疾病机制.
- 使用先进的药物发现平台和更相关的临床前模型进行疗效和毒性研究.
主要成果:
- 改善患者分层可以通过高通量分子技术开发有针对性的疗法.
- 没有偏见的"omic"方法为发现新的心血管疾病机制提供了潜力.
- 药物发现平台和临床前模型的进步可以加强治疗开发.
结论:
- 从发现到实施, 重新构想药物开发管道对于振兴心血管研究和投资至关重要.
- 需要在整个心血管治疗开发领域采用创新平台和方法.
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