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小分子抑制METTL3作为抗髓性白血病的策略

Eliza Yankova1,2,3, Wesley Blackaby3, Mark Albertella3

  • 1Milner Therapeutics Institute, University of Cambridge, Cambridge, UK.

Nature
|April 26, 2021
PubMed
概括

研究人员开发了STM2457, 这是一种针对METTL3的强有力的抑制剂, 这是一种在急性髓性白血病 (AML) 中至关重要的酶. 这一发现为AML提供了一个有前途的新治疗策略, 通过向癌细胞中的RNA修饰.

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