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通过类似癌症的机制,PIK3CA和CCM突变为洞穴生物提供燃料

Aileen A Ren1, Daniel A Snellings2, Yourong S Su3

  • 1Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA.

Nature
|April 28, 2021
PubMed
概括

由于PI3K-mTOR通路的激活和CCM复合体的丧失,大脑洞腔形 (CCM) 的增长. 像拉巴胺素这样的mtork1抑制剂在阻断CCM形成方面表现有前途,并且可以治疗侵袭性血管形.

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