在Drosophila大脑中的活动,新陈代谢和行为
Kevin Mann1, Stephane Deny2, Surya Ganguli3,4
1Department of Neurobiology, Stanford University, Stanford, CA, USA.
Nature
|April 29, 2021
概括
神经活动直接影响大脑中的能量代谢,显示神经功能与代谢流之间的强烈联系. 这一发现支持使用代谢测量来了解大脑活动.
科学领域:
- 神经科学
- 代谢生物学
- 系统生物学
背景情况:
- 协调的神经活动对于各种行为状态至关重要.
- 通过氧气消耗和葡萄糖吸收测量的能量代谢经常被用作神经活动的代理.
- 在行为过程中的完整电路中神经活动和代谢流之间的因果关系尚不清楚.
研究的目的:
- 在不同行为状态中实时调查神经活动和代谢流动之间的因果关系.
- 确定神经活动是否驱动行为相关时间尺度上的代谢变化.
- 探索神经元代谢的预测能力.
主要方法:
- 使用双光子显微镜同时测量大脑中的神经活动和代谢流量.
- 使用传感器实时监控静止状态和活动状态.
- 使用局部光遗传干扰来操纵神经活动.
主要成果:
- 证明神经活动会导致新陈代谢变化, 建立大脑网络之间的紧密合.
- 过渡性神经活动增加导致细胞质ATP的快速和持续增加.
- 发现即使是微小的行为动作也会引起神经活动和能量代谢的广泛变化.
结论:
- 神经活动是代谢流动的直接驱动因素,验证了代谢代理的使用以评估大脑功能.
- 神经元代谢似乎在预期未来的能源需求时积极分配资源.
- 行为启动涉及广泛的大脑网络,影响神经活动和能量代谢.
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