相关实验视频

Updated: Nov 7, 2025

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

模仿游戏:质母细胞瘤如何战胜免疫攻击

Ilon Liu¹, Olivia A Hack¹, Mariella G Filbin¹

¹Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02215, USA.

|April 30, 2021

概括

质母细胞通过劫持骨髓细胞回路来逃避免疫攻击. 这种免疫规避机制是大脑癌症抗药性的关键因素.

科学领域:

神经瘤学
癌症免疫学
表观遗传学

背景情况:

质母细胞瘤是一种致命的脑癌,
在质母细胞瘤治疗中,免疫逃避和对免疫疗法的抵抗是重大挑战.

研究的目的:

研究质母细胞细胞逃离免疫系统的机制.
了解瘤微环境在质母细胞瘤免疫规避中的作用.

主要方法:

对质母细胞细胞的转录和表观遗传特征的分析.
研究质母细胞瘤免疫微环境中的细胞相互作用.

主要成果:

质母细胞采用髓状特征的转录和表观遗传程序.
这些被采用的电路有助于瘤细胞逃离免疫系统.

结论:

瘤免疫微环境积极驱动质母细胞发展免疫逃避策略.
针对这些被劫持的骨髓回路可能为质母细胞瘤提供新的治疗途径.

更多相关视频

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

Published on: September 1, 2018

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Published on: June 2, 2023

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.