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相关概念视频

Gastrulation01:56

Gastrulation

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Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
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一个单个胚胎,单个细胞的时间解析模型用于小鼠胃化

Markus Mittnenzweig1, Yoav Mayshar2, Saifeng Cheng2

  • 1Department of Computer Science and Applied Mathematics and Department of Biological Regulation, Weizmann Institute of Science, 7610001 Rehovot, Israel.

Cell
|May 1, 2021
PubMed
概括

这项研究介绍了小鼠胃流动的时间模型,揭示了细胞命运的获取涉及复杂的多分支动态,而不仅仅是二进制选择. 这有助于我们更好地了解胚胎发育和细胞分化.

关键词:
细胞命运决定基梅拉试验发育生物学小鼠的胃化网络流量模型scRNA-seq 在四平体补充试验轨迹推断

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科学领域:

  • 发育生物学
  • 基因组学
  • 计算生物学

背景情况:

  • 小鼠胚胎发育是哺乳动物细胞命运的一个关键模型.
  • 单细胞地图可以绘制胚胎转录的地图.
  • 从这些图表中推断出协调的细胞动态是很有挑战性的.

研究的目的:

  • 开发小鼠胃流动的时间模型.
  • 推断差异化流程和血统规范的动态.
  • 挑战细胞命运的二元选择模型.

主要方法:

  • 使用了153个小鼠胚胎在36小时内单独取样的数据.
  • 使用算法和精确的时间来分析转录数据.
  • 使用时间匹配的Foxc1/Foxc2突变体的嵌合体胚胎来研究中皮体的发育.

主要成果:

  • 在胚胎转录多重体中推断分化流和谱系规范动态.
  • 确定了早期结节和血液细胞的快速转录分支.
  • 在大多数谱系中观察到组合的多分支动态,而不是等级过渡.

结论:

  • 在小鼠胃化过程中,细胞命运的获取由组合的多分支动态控制.
  • 这挑战了传统的差异化观点,
  • 为了解胚胎发育过程中的细胞命运获取提供了一个新的定量模型.