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Updated: Nov 7, 2025

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编辑RNA指南链的合理设计:孤儿位置的cytidine类似物

Erin E Doherty1, Xander E Wilcox1, Lenka van Sint Fiet2

  • 1Department of Chemistry, University of California, Davis, California 95616, United States.

Journal of the American Chemical Society
|May 3, 2021
PubMed
概括

导向链的修改增强了对RNA (ADARs) 作用的腺酶的活性,以精确编辑RNA. 核酸相似物稳定酶-RNA复合体,增加催化速率并通过定向RNA编辑改善疾病突变纠正.

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