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通过 SETDB1 的表观遗传沉默抑制了瘤内在的免疫性

Gabriel K Griffin1,2,3, Jingyi Wu1,2, Arvin Iracheta-Vellve1

  • 1Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Nature
|May 6, 2021
PubMed
概括

该研究确定SETDB1是抑制抗瘤免疫力的关键表观遗传调节剂. 通过激活免疫反应,SETDB1的丧失增强了癌细胞对免疫治疗的敏感性.

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