儿童期以来心血管风险因素轨迹和中年认知表现:年轻芬兰人的心血管风险研究
Juuso O Hakala1,2,3, Katja Pahkala1,2,3, Markus Juonala4,5
1Research Centre of Applied and Preventive Cardiovascular Medicine (J.O.H., K.P., P.S., O.T.R., S.P.R.), University of Turku, Finland.
Circulation
|May 10, 2021
概括
从童年到中年, 高血压和胆固醇等心血管风险因素会对认知功能产生负面影响. 风险因素越多, 成年后的认知能力就越差.
科学领域:
- 神经科学
- 心脏病学
- 公共卫生
背景情况:
- 中年人的心血管风险因素与认知能力下降有关.
- 从儿童时期积累的心血管风险因素对认知能力的影响的纵向数据有限.
研究的目的:
- 研究从童年到中年心血管风险因素之间的关联,它们的积累,以及成年人的认知表现.
主要方法:
- 对3596名儿童 (年龄在3-18岁) 的基于人口的队列进行了31年的跟踪.
- 对心血管风险因素 (血压,脂质,BMI) 进行了多次评估.
- 潜在类增长混合模型确定了风险因素轨迹;对2026名参与者进行了认知测试 (年龄在34-49岁之间).
主要成果:
- 持续高血压和总胆固醇与较差的情节性记忆和关联性学习有关.
- 儿童肥胖与视觉处理和持续注意力差异相关.
- 心血管风险因素的累积与情节性记忆,关联性学习,视觉处理,持续的注意力和反应时间有相反的关联.
结论:
- 从童年到中年, 血压升高,血清总胆固醇和肥胖与中年认知能力相反相关.
- 心血管风险因素的增加与认知功能的下降有关.
- 针对心血管风险因素的儿童早期干预策略可以促进成人认知健康.
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