突发L452RSARS-CoV-2变种的传播,感染性和中和性
Xianding Deng1, Miguel A Garcia-Knight2, Mir M Khalid3
1Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94158, USA; UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA 94158, USA.
Cell
|May 15, 2021
概括
一种新的严重急性呼吸综合征冠状病毒2 (SARS-CoV-2) 变种,B.1.427/B.1.429,在加利福尼亚州出现,其传染性和病毒流放性增加. 这种变体对康复患者和接种疫苗的人的抗体敏感性降低.
科学领域:
- 病毒学
- 基因组学
- 流行病学
背景情况:
- 新型严重急性呼吸综合征冠状病毒2 (SARS-CoV-2) 变种的出现构成了重大公共卫生挑战.
- 了解新变种的特征,包括传染性和免疫逃避,对于有效的流行病应对至关重要.
研究的目的:
- 确定和描述加利福尼亚州新出现的SARS-CoV-2变种.
- 评估已识别的变种的传染性,病毒分泌和抗体中和.
主要方法:
- 2,172个鼻腔/鼻抽样的全基因组测序.
- 随着时间的推移而变种流行率的分析.
- 包括伪病毒感染测定和抗体中和测定在内的体外研究.
主要成果:
- 鉴定了B.1.427/B.1.429变种,该变种在2020年9月至2021年1月期间在加利福尼亚州的测序病例中从0%增加到50%以上.
- 与野生型菌株相比,该变种的传染性增加了18.6% - 24%,病毒分泌量增加了2倍.
- 在康复期患者和接种疫苗的患者中,抗体中和定量分别降低了4. 0至6. 7倍和2. 0倍.
结论:
- 在加利福尼亚传播的B.1.427/B.1.429变种是一种更易传播的SARS-CoV-2菌株.
- 这种变体对康复期患者和接种疫苗的抗体的中和感受性降低.
- 由于这种变种的流行率增加及其对公共卫生干预措施的潜在影响,需要进一步调查.
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