在人体中,SARS-CoV-2 感染会诱导长寿的骨髓血细胞
Jackson S Turner1, Wooseob Kim1, Elizaveta Kalaidina2
1Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Nature
|May 24, 2021
概括
轻微的COVID-19感染可以建立长期的免疫记忆. 生长时间的骨髓等离子细胞 (BMPC) 产生SARS-CoV-2抗体,持续至少11个月,确保强大的免疫力.
科学领域:
- 免疫学
- 病毒学
- 传染性疾病
背景情况:
- 长寿命的骨髓血细胞 (BMPC) 对于持续的抗体产生和保护免疫力至关重要.
- 从COVID-19中恢复过来的个体具有较低的再感染风险,但由于抗体水平的下降,人们对短暂的幽默免疫力存在担忧.
- 在轻度感染后,SARS-CoV-2特异性BMPCs的产生和持久性尚不完全理解.
研究的目的:
- 在轻微的COVID-19后调查SARS-CoV-2特异性骨髓血细胞 (BMPC) 的生成和寿命.
- 确定轻微的SARS-CoV-2感染是否会诱导持久的幽默免疫记忆.
- 评估这些产生抗体的细胞的特征及其与血清抗体水平的相关性.
主要方法:
- 随着时间的推移 (长达11个月) 在康复期的个体中分析血清抗SARS-CoV-2抗体水平的峰值 (S).
- 从康复个体和健康对照中抽取骨髓中的S特异性血细胞的量化.
- 评估BMPC特征 (静止) 和检测循环记忆B细胞.
主要成果:
- 在感染后的前4个月中,血清抗SARS-CoV-2 S抗体水平适度下降,然后稳定,至少可检测11个月.
- 在感染后7-8个月的康复个体的骨髓吸附物中检测到S特异性BMPCs,与抗体标位相关.
- 也发现了循环记忆B细胞.
结论:
- 轻微的SARS-CoV-2感染会在人类中产生强大且长期存在的抗原特异性幽默免疫记忆.
- 产生持久,静止的S特异性BMPCs有助于维持抗体水平和防止再感染.
- 这些发现支持天然SARS-CoV-2感染所带来的长期保护性免疫力.
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