一个不变的Trypanosoma vivax疫苗抗原诱导保护性免疫力
Delphine Autheman1, Cécile Crosnier1, Simon Clare2
1Cell Surface Signalling Laboratory, Wellcome Sanger Institute, Hinxton, UK.
Nature
|May 27, 2021
概括
研究人员发现了Trypanosoma vivax中一种关键蛋白质 - - 一种不变的鞭毛抗原 - - 能够对寄生虫产生长期的保护. 这一发现为非洲三虫病和相关牲畜疾病提供了有前途的疫苗候选人.
科学领域:
- 寄生虫学
- 免疫学
- 疫苗学
背景情况:
- 试素会引起人类和牲畜的重大疾病.
- 试管体中的抗原变异阻碍了疫苗的开发.
- 非洲三虫病影响撒哈拉以南非洲的社会经济发展.
研究的目的:
- 为了识别对Trypanosoma寄生虫的不变疫苗抗原.
- 开发一种潜在的非洲试和纳纳病毒疫苗.
主要方法:
- 基因组为主导的疫苗学方法.
- 感染Trypanosoma vivax的小鼠模型
- 用复合不变鞭子抗原进行疫苗接种.
主要成果:
- 一种单一的重组蛋白 (不变的鞭毛抗原) 诱导了长期的保护.
- 免疫可以通过血清和单克隆抗体转移.
- 抗体介导免疫包括补充激活.
结论:
- 确定了一种有前途的疫苗候选人.
- 证明了实现高保护性试体疫苗的可行性.
- 突出抗体和补充在免疫中的作用.
更多相关视频
08:46Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites
Published on: May 18, 2016
17.8K
07:05In Vivo Assay for Detection of Antigen-specific T-cell Cytolytic Function Using a Vaccination Model
Published on: November 28, 2017
10.1K
相关概念视频
Vaccinations
48.3K
Overview
48.3K
Antigens Involved in Adaptive Immunity
864
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
864
Cross-reactivity
31.9K
Overview
31.9K
Immunological Memory
13.4K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
13.4K
Cancer Vaccines
597
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
597
Development of Immunocompetence
552
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
552
